Thanos discovered the infant Gamora after the whole of the Zen-Whoberis race had been wiped of by the Universal Church of Truth. Thanos used the machines aboard his ship, Sanctuary II, to bring Gamora back in time by two decades and bring her body to peak perfection. He also altered Gamora's perceptions, so that she would not see how evil he was.

Thanos sent Gamora into the Universal Church Of Truth, hoping she would cause chaos and also assassinate the Church's leader, the Magus. Gamora then aided Adam Warlock against the Magus, leading to the Magus' defeat.

Returning back to Thanos, Gamora saw his true nature and tried to stop him. Thanos slew Gamora but Warlock found her and placed her soul inside the Soul Gem.

Sometime later, when Thanos gained the Infinity Gauntlet, Gamora (along with Adam Warlock and Pip) were brought back to life and gained new bodies. After Adam gained control of the Infinity Gauntlet he gave the Time Gem to Gamora, and made her a member of the Infinity Watch.

Gamora took up residence on Monster Island, even defending the island from an U.N. invasion. Gamora helped Galactus revive Eternity and then helped the Infinity Watch stop the Goddess.

When a being from another universe stole the Infinity Gems, the Watch was disbanded. Since then, Gamora has helped battle evil Thanos clones, trained She-Hulk for a battle with Champion and engaged Ronan.